Alpha-1 receptor stimulation primarily causes which effect?

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Multiple Choice

Alpha-1 receptor stimulation primarily causes which effect?

Explanation:
Stimulation of alpha-1 receptors primarily causes vasoconstriction of vascular smooth muscle. These receptors are on arterioles and venules; when activated, they trigger a Gq signaling pathway that leads to phospholipase C activation, production of IP3 and DAG, and a rise in intracellular calcium. The calcium causes smooth muscle contraction, narrowing the vessels, increasing systemic vascular resistance, and raising blood pressure. Bronchodilation is mainly a beta-2 effect, and a decreased heart rate is not a direct result of alpha-1 activation (it may occur secondarily if blood pressure rises and reflex bradycardia ensues).

Stimulation of alpha-1 receptors primarily causes vasoconstriction of vascular smooth muscle. These receptors are on arterioles and venules; when activated, they trigger a Gq signaling pathway that leads to phospholipase C activation, production of IP3 and DAG, and a rise in intracellular calcium. The calcium causes smooth muscle contraction, narrowing the vessels, increasing systemic vascular resistance, and raising blood pressure. Bronchodilation is mainly a beta-2 effect, and a decreased heart rate is not a direct result of alpha-1 activation (it may occur secondarily if blood pressure rises and reflex bradycardia ensues).

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