The classic triad of symptoms in opioid overdose includes coma, pinpoint pupils, and which finding?

• A. Respiratory depression
• B. Chest pain
• C. Hypertension
• D. Diarrhea

Answer: (A)

Opioid overdose typically slows the brainstem’s control of breathing, so respiratory depression becomes the defining missing piece of the triad alongside coma and pinpoint pupils. The depressed drive to breathe reduces breathing rate and depth, risking hypoxia and further CNS depression, which is why this sign is the best answer.

Chest pain isn’t characteristic of opioid overdose and would point toward a cardiac or pulmonary issue. Hypertension is not typical here; opioids can cause hypotension rather than high blood pressure. Diarrhea is the opposite of the common opioid effect, which is constipation, not loose stools.